Bullous (meaning "related to blisters") pemphigoid is a blistering disease that is seen most commonly in elderly persons. Unlike pemphigus, where loose and broken blisters are seen, pemphigoid produces large, tense blisters of the skin and, rarely, the mucous membranes. Blisters form when the patient's own antibodies (immune proteins) attack a specific layer in the skin, causing a separation between layers where fluid accumulates. In pemphigoid, this separation occurs between deeper layers of the skin, and, as a result, the blisters are stronger and don't break as easily.
Cause of Pemphigoid
Most cases of pemphigoid occur without a known inciting cause.