Signs and Symptoms of Pemphigoid
The skin blisters of pemphigoid are characteristically large and tense. They usually are seen on top of reddened skin and commonly appear on the abdomen, thighs, and forearms. Mucous membrane involvement is seen in fewer than one-third of patients.
The clinical presentation of pemphigoid can be quite distinct. Laboratory confirmation is obtained by skin biopsy for routine pathological examination and for specialized immunofluorescence, a procedure that identifies which of the patient's antibodies is present in the skin, thus distinguishing it from other blistering diseases.