Researchers assigned 641 patients with chronic fatigue syndrome to 52 weeks of one of four therapies:

  • Standard medical care (written generic advice);
  • adaptive pacing (strategies for adapting to the condition, such as prioritizing activities, limiting stress and conserving energy);
  • cognitive behavioral therapy (learning how to change behaviors, such as avoiding physical activity); and
  • graded exercise (incrementally increasing activity up to normal levels).

Only those who participated in cognitive behavioral therapy or graded exercise reported less fatigue and improved physical function.

Source: The Lancet, vol. 377, p. 823; Prepared by the Editors of The Johns Hopkins Medical Letter: Health After 50

Publication Review By: the Editorial Staff at

Published: 07 Jul 2013

Last Modified: 07 Jul 2013