Nonsteroidal Anti-Inflammatory Drugs

Leukotriene modifiers inhibit immune reactions that cause inflammation and reduce constriction of bronchi. The are not for immediate relief of asthma attack. Tell your doctor if you are a heavy drinker or have had liver disease. These medications may (rarely) cause liver damage. If you have aspirin sensitivity, avoid taking aspirin and NSAIDs while taking Singulair.

Leukotrien modifiers and their daily dosages include the following:

  • Accolate (zafirlukast)—20 mg 2x/day
  • Singulair (montelukast)—10 mg/day
  • Zyflo (zileuton)—600 mg 4x/day

Accolate should be taken at least 1 hour before or 2 hours after meals. Singulair should be taken at night, with or without food. To prevent exercise-induced asthma, take this drug at least 2 hours before exercise. Zyflo may be taken with or without food.

Side Effects of Oral Leukotriene Modifiers

Accolate and Zyflo may cause headache, flu-like symptoms, abdominal pain, diarrhea, indigestion, rash. Singulair can cause stomach pain, gastrointestinal upset, heartburn, tiredness, fever, stuffy nose, cough. Call your doctor if you take Accolate or Zyflo and have a rash, flu-like symptoms, nausea, loss of appetite, weakness, unusually dark urine, yellowing skin, worsening asthma. If you take Singulair and develop tingling or numbness in the arms or legs, flu-like symptoms, rash, severe sinus inflammation or behavioral or mood-related changes such as agitation, depression, anxiety, suicidal thoughts or trouble sleeping, contact your health care provider.

Publication Review By: Peter B. Terry, M.D., M.A.

Published: 24 Jun 2013

Last Modified: 24 Jun 2013