Information about Cognitive Decline Risk and Digestive Disorder Medications

The authors of an Archives of Internal Medicine study assigned a number (1, 2, or 3) to drugs used to treat digestive disorders. A rating of 1 means that they have some potential for anticholinergic side effects (including memory loss and cognitive decline); a 2 means that they have moderate potential; and a 3 means that they have high potential.

  • dicyclomine (Bentyl)—used to treat irritable bowel syndrome (IBS); anticholinergic score: 3
  • hyoscyamine (Levbid)—used to treat IBS, peptic ulcers, diverticulitis and pancreatitis; anticholinergic score: 3
  • diphenoxylate/atropine (Lomotil)—used to treat diarrhea; anticholinergic score 3
  • loperamide (Imodium A-D)—used to treat diarrhea; anticholinergic score 2
  • cimetidine (Tagamet)—used to treat gastroesophageal reflux disease (GERD); anticholinergic score: 2
  • metoclopramide (Reglan)—used to treat GERD; anticholinergic score: 1
  • ranitidine (Zantac)—used to treat GERD; anticholinergic score: 1

Publication Review By: H. Franklin Herlong, M.D.

Published: 31 Mar 2011

Last Modified: 02 Dec 2014