Information about Combination Glaucoma Medicine Dosages, Precautions & Side Effects

Combination medicines use in glaucoma treatment include Combigan (brimonidine-timolol) and Cosopt (dorzolamide-timolol). Typical daily dose of these medications is 1 eyedrop 2x/day. Combigan is a combination adrenergic agonist and beta-blocker and Cosopt is a combination carbonic anhydrase inhibitor and beta-blocker.

Patients using brimondine-timolol to treat glaucoma should wait 5 minutes before using any other eyedrops and patients using dorzolamide-timolol) should wait 2 minutes.

Common side effects associated with brimonidine-timolol include the following:

  • itchy, irritated eyes
  • eye swelling or pain, blurred vision, double vision
  • increased sensitivity to light and glare
  • headache
  • drowsiness
  • difficulty falling asleep or staying asleep
  • dry mouth
  • cold- or flu-like symptoms
  • depression
  • dizziness
  • nausea

Common side effects associated with dorzolamide-timolol include:

  • eye irritation (tearing, burning, stinging, redness)
  • double, blurred, or cloudy vision
  • blurred vision
  • headache
  • depression
  • dizziness
  • nausea
  • insomnia
  • sensitivity to light

Publication Review By: Susan B. Bressler, M.D., Harry A. Quigley, M.D., Oliver D. Schein, M.D., M.P.H.

Published: 04 Mar 2011

Last Modified: 07 Jan 2015