Information below provides a rundown of how researchers rated NSAIDs. These risks may be incurred within the first month of use.

Naproxen (Aleve, Anaprox, Naprelan, Naprosyn)—Both prescription and over-the-counter (OTC) doses are safest among NSAIDs for both high- and low-risk individuals.

Ibuprofen (Advil, Motrin, Nuprin)—Low doses of OTC ibuprofen are safest, but as prescription doses rise above 1,200 mg a day, so does cardiac risk.

Celeoxib (Celebrex)—Both low and high doses showed a slightly increased cardiac risk, and the study authors say they'd be "reluctant" to prescribe it to high-risk patients.

Indomethacin (Indocin)—Considered high risk. Given its gastrointestinal and nervous system risks, the authors advise removing it from the market.

Piroxicam (Feldene)—Risk is similar to that of naproxen, but it has a very high risk of serious gastrointestinal disturbances.

Meloxicam (Mobic)—Risk is similar to that of ibuprofen and celeoxib, but it should be avoided by high-risk persons.

Etodolac (Lodine)—Sparse data make this a questionable choice. When compared with naproxen and ibuprofen, risk was similar, but on its own, some studies found it to be high risk.

Source: Prepared by the Editors of The Johns Hopkins Medical Letter: Health After 50

Publication Review By: the Editorial Staff at

Published: 09 Jul 2013

Last Modified: 18 Sep 2015