These antihypertensive agents affect the central nervous system (brain) to decrease blood pressure. Such medications include clonidine (Catapres) and methyldopa (Aldomet). Because these drugs act directly on the brain, they occasionally cause drowsiness, depression, and other symptoms.

Publication Review By: Jagdish Patel, M.D., F.A.C.C.

Published: 29 Jun 2000

Last Modified: 21 Sep 2015