Huntington's Disease Cause and Risk Factor

Having a parent with Huntington's is the risk factor. A child of an affected parent has a 50% chance of inheriting the disease.

The genetic mutation that occurs in gene IT-15, located on chromosome 4, alters the huntington protein, which is present in all human beings, and causes Huntington's disease. How the mutation of gene IT-15 alters the function of the protein is not well understood.

Publication Review By: Stanley J. Swierzewski, III, M.D.

Published: 02 Jan 2000

Last Modified: 19 May 2011