Oral Diabetes Medications


Meglitinides work in the same way as sulfonylureas, by stimulating the pancreas to release more insulin into the bloodstream. Repaglinide (Prandin) is the only meglitinide approved by the FDA. It is taken before meals and increases insulin levels much faster than sulfonylureas.

Hypoglycemia, the most common side effect, occurs less often with Prandin than with sulfonylureas. Prandin takes effect quickly, so you must eat soon after taking it and consume carbohydrate-rich foods to prevent blood glucose levels from falling too low.

If Prandin doesn't sufficiently control your blood glucose, your doctor may add another drug such as metformin, an alpha-glucosidase inhibitor, or a thiazolidinedione.

Publication Review By: Written by: Christopher D. Saudek, M.D.; Simeon Margolis, M.D., Ph.D.

Published: 21 Apr 2009

Last Modified: 10 Mar 2015